Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

olig2-Expressing hindbrain cells are required for migrating facial motor neurons.

http://www.ncbi.nlm.nih.gov/pubmed/22275004

The complicated trajectory of facial motor neuron migration requires coordination of intrinsic signals and cues from the surrounding environment. Migration begins in rhombomere (r) 4 where facial motor neurons are born and proceeds in a caudal direction. Once facial motor neurons reach their target rhombomeres, they migrate laterally and radially from the ventral neural tube. In zebrafish, as facial motor neurons migrate through r5/r6, they pass near cells that express olig2, which encodes a bHLH transcription factor. In this study, we found that olig2 function is required for facial motor neurons to complete their caudal migration into r6 and r7 and form stereotypical clusters. Additionally, embryos that lack mafba function, in which facial motor neurons also fail to complete caudal migration, lack olig2 expression in r5 and r6. Our data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.

Pubmed ID: 22275004 RIS Download

Mesh terms: Animals | Animals, Genetically Modified | Basic Helix-Loop-Helix Transcription Factors | Body Patterning | Cell Movement | Motor Neurons | Nerve Tissue Proteins | Rhombencephalon | Zebrafish | Zebrafish Proteins

Research resources used in this publication

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIMH NIH HHS, Id: MH064913
  • Agency: NINDS NIH HHS, Id: NS038183
  • Agency: NINDS NIH HHS, Id: NS046668
  • Agency: NINDS NIH HHS, Id: R01 NS038183
  • Agency: NINDS NIH HHS, Id: R01 NS046668
  • Agency: NINDS NIH HHS, Id: R01 NS046668-06A1
  • Agency: NIMH NIH HHS, Id: T32 MH064913

ZFIN (Data, Gene Expression)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.