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ZBTB1 is a determinant of lymphoid development.

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Pubmed ID: 22201126 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | Female | Gene Expression Regulation, Developmental | Hematopoietic Stem Cells | Lymphocytes | Lymphopenia | Lymphopoiesis | Male | Mice | Mice, Inbred C3H | Mice, Inbred C57BL | Molecular Sequence Data | Mutation | Myeloid Cells | Repressor Proteins | T-Lymphocytes | Zinc Fingers

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Associated grants

  • Agency: NIAID NIH HHS, Id: HHSN272200700038C
  • Agency: NIGMS NIH HHS, Id: R37 GM067759

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Jackson Laboratory

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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