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ZBTB1 is a determinant of lymphoid development.

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Pubmed ID: 22201126


  • Siggs OM
  • Li X
  • Xia Y
  • Beutler B


The Journal of experimental medicine

Publication Data

January 16, 2012

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R37 GM067759

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Female
  • Gene Expression Regulation, Developmental
  • Hematopoietic Stem Cells
  • Lymphocytes
  • Lymphopenia
  • Lymphopoiesis
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Mutation
  • Myeloid Cells
  • Repressor Proteins
  • T-Lymphocytes
  • Zinc Fingers