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ZBTB1 is a determinant of lymphoid development.

http://www.ncbi.nlm.nih.gov/pubmed/22201126

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Pubmed ID: 22201126 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | Female | Gene Expression Regulation, Developmental | Hematopoietic Stem Cells | Lymphocytes | Lymphopenia | Lymphopoiesis | Male | Mice | Mice, Inbred C3H | Mice, Inbred C57BL | Molecular Sequence Data | Mutation | Myeloid Cells | Repressor Proteins | T-Lymphocytes | Zinc Fingers

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R37 GM067759

Mouse Genome Informatics (Data, Gene Annotation)

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