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ZBTB1 is a determinant of lymphoid development.

The Journal of experimental medicine | 2012

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Pubmed ID: 22201126 RIS Download

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: HHSN272200700038C
  • Agency: NIGMS NIH HHS, United States
    Id: R37 GM067759

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C3H/HeN (tool)

RRID:MGI:2160972

laboratory mouse with name C3H/HeN from MGI.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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