Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

ART: a next-generation sequencing read simulator.

ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles. AVAILABILITY: Both source and binary software packages are available at

Pubmed ID: 22199392


  • Huang W
  • Li L
  • Myers JR
  • Marth GT


Bioinformatics (Oxford, England)

Publication Data

February 15, 2012

Associated Grants

  • Agency: NIEHS NIH HHS, Id: ES101765
  • Agency: NHGRI NIH HHS, Id: HG003698
  • Agency: NHGRI NIH HHS, Id: HG004719
  • Agency: Intramural NIH HHS, Id:

Mesh Terms

  • Chromosomes, Human, Pair 17
  • Genetic Variation
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Sequence Analysis, DNA
  • Software