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A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.

NSP 5a3a is a novel structural protein found to be over-expressed in certain cancer cell lines in-vitro such as Hela, Saos-2, and MCF-7 while barely detectable levels in normal body tissues except for Testis. This particular isoform has been known to interact with cyto- nuclear proteins B23, known to be involved in multi-faceted cellular processes such as cell division, apoptosis, ribosome biogenesis, and rRNA processing, as well as with hnRNP-L, known to be involved with RNA metabolism and rRNA processing. A previous preliminary investigation of NSP 5a3a as a potential target in Head and Neck Carcinoma revealed a novel p73 dependent mechanism through which NSP 5a3a induced apoptosis in Head and Neck cell lines when over-expressed in-vitro. Our present investigation further elucidated a novel dual axis signaling point by which NSP 5a3a induces apoptosis in Head and Neck cell line HN30 through p73-DAXX and TRAF2-TRADD. Interestingly, this novel mechanism appears independent of canonical caspases involved in the intrinsic mitochondrial pathway as well as those in the death receptor pathway thru TRAF2 and TRADD.

Pubmed ID: 22170762

Authors

  • D'Agostino L
  • Giordano A

Journal

Oncotarget

Publication Data

December 23, 2011

Associated Grants

None

Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Apoptosis
  • Carcinoma, Squamous Cell
  • Cell Division
  • Cell Line, Tumor
  • DNA-Binding Proteins
  • Head and Neck Neoplasms
  • Humans
  • Nuclear Proteins
  • Signal Transduction
  • TNF Receptor-Associated Death Domain Protein
  • TNF Receptor-Associated Factor 2
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
  • Tumor Suppressor Proteins