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microRNA-34a regulates neurite outgrowth, spinal morphology, and function.

The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and syntaxin-1A. Here we show that this axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype. Moreover, overexpression of miR-34a alters hippocampal spinal morphology, and results in electrophysiological changes consistent with a reduction in spinal function. Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development.

Pubmed ID: 22160706 RIS Download

Mesh terms: Animals | Blotting, Western | Cell Differentiation | Electrophysiology | Embryonic Stem Cells | Mice | Mice, Knockout | MicroRNAs | Neurites | Nuclear Proteins | Real-Time Polymerase Chain Reaction | Spine | Synaptotagmin I | Syntaxin 1

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Associated grants

  • Agency: Medical Research Council, Id: MRC_MC_U132670600
  • Agency: Telethon, Id: TI_GGP09133

Mouse Genome Informatics (Data, Gene Annotation)

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