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Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells.

Science (New York, N.Y.) | Dec 23, 2011

B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not need any lamins for self-renewal and pluripotency. Although genome-wide lamin-B binding profiles correlate with reduced gene expression, such binding is not directly required for gene silencing in ESCs or trophectoderm cells. However, B-type lamins are required for proper organogenesis. Defects in spindle orientation in neural progenitor cells and migration of neurons probably cause brain disorganizations found in lamin-B null mice. Thus, our studies not only disprove several prevailing views of lamin-Bs but also establish a foundation for redefining the function of the nuclear lamina in the context of tissue building and homeostasis.

Pubmed ID: 22116031 RIS Download

Mesh terms: Animals | Body Size | Brain | Cell Cycle | Cell Differentiation | Cell Movement | Cells, Cultured | Chromatin | Embryonic Development | Embryonic Stem Cells | Female | Gene Expression Regulation, Developmental | Gene Silencing | Lamin Type B | Male | Mice | Mice, Knockout | Neural Stem Cells | Neurons | Nuclear Lamina | Organ Size | Organogenesis | Pluripotent Stem Cells | Promoter Regions, Genetic | Spindle Apparatus | Transcription, Genetic | Trophoblasts

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Associated grants

  • Agency: NIAMS NIH HHS, Id: R01 AR060042-02
  • Agency: NIAMS NIH HHS, Id: R01 AR060042
  • Agency: NIGMS NIH HHS, Id: R01 GM056312
  • Agency: Intramural NIH HHS, Id: R01 GM 56312
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: NIGMS NIH HHS, Id:

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