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InterPro in 2011: new developments in the family and domain prediction database.

InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites, and makes it freely available to the public via Web-based interfaces and services. Central to the database are diagnostic models, known as signatures, against which protein sequences can be searched to determine their potential function. InterPro has utility in the large-scale analysis of whole genomes and meta-genomes, as well as in characterizing individual protein sequences. Herein we give an overview of new developments in the database and its associated software since 2009, including updates to database content, curation processes and Web and programmatic interfaces.

Pubmed ID: 22096229


  • Hunter S
  • Jones P
  • Mitchell A
  • Apweiler R
  • Attwood TK
  • Bateman A
  • Bernard T
  • Binns D
  • Bork P
  • Burge S
  • de Castro E
  • Coggill P
  • Corbett M
  • Das U
  • Daugherty L
  • Duquenne L
  • Finn RD
  • Fraser M
  • Gough J
  • Haft D
  • Hulo N
  • Kahn D
  • Kelly E
  • Letunic I
  • Lonsdale D
  • Lopez R
  • Madera M
  • Maslen J
  • McAnulla C
  • McDowall J
  • McMenamin C
  • Mi H
  • Mutowo-Muellenet P
  • Mulder N
  • Natale D
  • Orengo C
  • Pesseat S
  • Punta M
  • Quinn AF
  • Rivoire C
  • Sangrador-Vegas A
  • Selengut JD
  • Sigrist CJ
  • Scheremetjew M
  • Tate J
  • Thimmajanarthanan M
  • Thomas PD
  • Wu CH
  • Yeats C
  • Yong SY


Nucleic acids research

Publication Data

January 23, 2012

Associated Grants

  • Agency: Biotechnology and Biological Sciences Research Council, Id: BB/F010435/1
  • Agency: Biotechnology and Biological Sciences Research Council, Id: BB/F010508/1
  • Agency: Biotechnology and Biological Sciences Research Council, Id: BB/G022771/1
  • Agency: NIGMS NIH HHS, Id: GM081084

Mesh Terms

  • Databases, Protein
  • Protein Structure, Tertiary
  • Proteins
  • Sequence Analysis, Protein
  • Software
  • Terminology as Topic
  • User-Computer Interface