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Interconversion between intestinal stem cell populations in distinct niches.

Science (New York, N.Y.) | Dec 9, 2011

http://www.ncbi.nlm.nih.gov/pubmed/22075725

Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cycling and label-retaining, whereas a different stem cell niche located at the crypt base is occupied by crypt base columnar (CBC) cells. CBCs are distinct from +4 cells, and the relationship between them is unknown, though both give rise to all intestinal epithelial lineages. We demonstrate that Hopx, an atypical homeobox protein, is a specific marker of +4 cells. Hopx-expressing cells give rise to CBCs and all mature intestinal epithelial lineages. Conversely, CBCs can give rise to +4 Hopx-positive cells. These findings demonstrate a bidirectional lineage relationship between active and quiescent stem cells in their niches.

Pubmed ID: 22075725 RIS Download

Mesh terms: Animals | Cell Cycle | Cell Differentiation | Cell Lineage | Cell Proliferation | Cells, Cultured | Epithelial Cells | Homeodomain Proteins | Intestinal Mucosa | Intestine, Small | Mice | Models, Biological | Multipotent Stem Cells | Paneth Cells | Stem Cell Niche | Tamoxifen

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Associated grants

  • Agency: NHLBI NIH HHS, Id: R01 HL071546
  • Agency: NHLBI NIH HHS, Id: R01 HL071546
  • Agency: NHLBI NIH HHS, Id: U01 HL100405
  • Agency: NHLBI NIH HHS, Id: U01 HL100405

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