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Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy.

We have developed a method for automated probabilistic reconstruction of a set of major white-matter pathways from diffusion-weighted MR images. Our method is called TRACULA (TRActs Constrained by UnderLying Anatomy) and utilizes prior information on the anatomy of the pathways from a set of training subjects. By incorporating this prior knowledge in the reconstruction procedure, our method obviates the need for manual interaction with the tract solutions at a later stage and thus facilitates the application of tractography to large studies. In this paper we illustrate the application of the method on data from a schizophrenia study and investigate whether the inclusion of both patients and healthy subjects in the training set affects our ability to reconstruct the pathways reliably. We show that, since our method does not constrain the exact spatial location or shape of the pathways but only their trajectory relative to the surrounding anatomical structures, a set a of healthy training subjects can be used to reconstruct the pathways accurately in patients as well as in controls.

Pubmed ID: 22016733 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, Id: U24 RR021382
  • Agency: NIBIB NIH HHS, Id: K99 EB008129
  • Agency: NIMH NIH HHS, Id: U01 MH093765
  • Agency: NINDS NIH HHS, Id: R01 NS070963
  • Agency: NCRR NIH HHS, Id: S10 RR019307
  • Agency: NCRR NIH HHS, Id: P41 RR014075
  • Agency: NINDS NIH HHS, Id: R01 NS052585
  • Agency: Medical Research Council, Id: MRC_G0800578
  • Agency: NCCIH NIH HHS, Id: RC1 AT005728
  • Agency: NIMH NIH HHS, Id: U54 MH091657
  • Agency: NINDS NIH HHS, Id: R21 NS072652
  • Agency: NCRR NIH HHS, Id: S10 RR023043
  • Agency: NIBIB NIH HHS, Id: R00 EB008129
  • Agency: NIBIB NIH HHS, Id: R01 EB006758
  • Agency: NCRR NIH HHS, Id: S10 RR023401
  • Agency: NIA NIH HHS, Id: R01 AG022381

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