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Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through which Aurora-A activity regulates the structure and cohesion of spindle poles.
Pubmed ID: 22011530 RIS Download
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Cell line U2OS is a Cancer cell line with a species of origin Homo sapiens (Human)
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