Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.

Genes & development | Oct 1, 2011

The biological response to tumor necrosis factor (TNF) involves activation of MAP kinases. Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho GTPase family members Rac/Cdc42. This signaling pathway requires Src-dependent activation of the guanosine nucleotide exchange factor Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site (CRIB motif) on mixed-lineage protein kinases (MLKs). We show that this pathway is essential for full MAP kinase activation during the response to TNF. Moreover, this MLK pathway contributes to inflammation in vivo.

Pubmed ID: 21979919 RIS Download

Mesh terms: Animals | Cells, Cultured | Enzyme Activation | Inflammation | Mice | Mice, Inbred C57BL | Mitogen-Activated Protein Kinases | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Proto-Oncogene Proteins c-akt | Proto-Oncogene Proteins c-vav | Signal Transduction | Tumor Necrosis Factor-alpha | Tyrosine | cdc42 GTP-Binding Protein

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: AI06107
  • Agency: NCI NIH HHS, Id: CA065861
  • Agency: NCI NIH HHS, Id: CA126937
  • Agency: NIDDK NIH HHS, Id: DK52530
  • Agency: NCI NIH HHS, Id: R37 CA049152
  • Agency: Howard Hughes Medical Institute, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.