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TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.

The biological response to tumor necrosis factor (TNF) involves activation of MAP kinases. Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho GTPase family members Rac/Cdc42. This signaling pathway requires Src-dependent activation of the guanosine nucleotide exchange factor Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site (CRIB motif) on mixed-lineage protein kinases (MLKs). We show that this pathway is essential for full MAP kinase activation during the response to TNF. Moreover, this MLK pathway contributes to inflammation in vivo.

Pubmed ID: 21979919

Authors

  • Kant S
  • Swat W
  • Zhang S
  • Zhang ZY
  • Neel BG
  • Flavell RA
  • Davis RJ

Journal

Genes & development

Publication Data

October 1, 2011

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI06107
  • Agency: NCI NIH HHS, Id: CA065861
  • Agency: NCI NIH HHS, Id: CA126937
  • Agency: NIDDK NIH HHS, Id: DK52530
  • Agency: NCI NIH HHS, Id: R37 CA049152
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Animals
  • Cells, Cultured
  • Enzyme Activation
  • Inflammation
  • Mice
  • Mice, Inbred C57BL
  • Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-vav
  • Signal Transduction
  • Tumor Necrosis Factor-alpha
  • Tyrosine
  • cdc42 GTP-Binding Protein