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Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network.

The sample included 343 opioid-dependent adults enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Opioid-dependent individuals were recruited from 12 sites across the United States from January 2001 to July 2002. We examined associations between depressive symptoms, co-occurring substance use (i.e., the use of substances other than opioids), and HIV-related sexual and injection risk behaviors. Data were collected using the Addiction Severity Index and the HIV Risk Behavior Scale, and analyzed using linear regression. Depressive symptoms were associated with an increased level of injection risk behaviors but were not associated with risky sexual behaviors. The co-occurring use of amphetamines also increased the likelihood of risky sexual behaviors. The study limitations and clinical implications are noted. The study was funded by the U.S. National Institute on Drug Abuse.

Pubmed ID: 21973307

Authors

  • Pilowsky DJ
  • Wu LT
  • Burchett B
  • Blazer DG
  • Ling W

Journal

Substance use & misuse

Publication Data

October 26, 2011

Associated Grants

  • Agency: NIDA NIH HHS, Id: HHSN271200522071C
  • Agency: PHS HHS, Id: HSN271200522071C
  • Agency: NIDA NIH HHS, Id: K05 DA017009
  • Agency: NIDA NIH HHS, Id: R01 DA019623
  • Agency: NIDA NIH HHS, Id: R01 DA019901
  • Agency: NIDA NIH HHS, Id: R01DA019623
  • Agency: NIDA NIH HHS, Id: R01DA019901
  • Agency: NIDA NIH HHS, Id: R21 DA027503
  • Agency: NIDA NIH HHS, Id: R21DA027503
  • Agency: NIDA NIH HHS, Id: R33 DA027503
  • Agency: NIDA NIH HHS, Id: R33DA027503
  • Agency: NIDA NIH HHS, Id: U10 DA013043
  • Agency: NIDA NIH HHS, Id: U10 DA013045
  • Agency: NIDA NIH HHS, Id: U10 DA013045

Mesh Terms

  • Adolescent
  • Adult
  • Amphetamine-Related Disorders
  • Behavior, Addictive
  • Cross-Sectional Studies
  • Depression
  • Female
  • HIV Infections
  • HIV Seropositivity
  • Humans
  • Male
  • Middle Aged
  • Opioid-Related Disorders
  • Risk-Taking
  • Sexual Behavior