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Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.

http://www.ncbi.nlm.nih.gov/pubmed/21873235

The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required for optimal NF-κB activation, but little is known about the responsible substrate(s). Here we report that Malt1 cleaved the NF-κB family member RelB after Arg-85. RelB cleavage induced its proteasomal degradation and specifically controlled DNA binding of RelA- or c-Rel-containing NF-κB complexes. Overexpression of RelB inhibited expression of canonical NF-κB target genes and led to impaired survival of diffuse large B-cell lymphoma cell lines characterized by constitutive Malt1 activity. These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment.

Pubmed ID: 21873235 RIS Download

Mesh terms: Caspases | Cell Line, Tumor | Humans | Lymphocyte Activation | Lymphocytes | Lymphoma, Large B-Cell, Diffuse | NF-kappa B | Neoplasm Proteins | Transcription Factor RelA | Transcription Factor RelB

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