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Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290-295(-/-) mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure.

Pubmed ID: 21844366


  • Medeiros LA
  • Dennis LM
  • Gill ME
  • Houbaviy H
  • Markoulaki S
  • Fu D
  • White AC
  • Kirak O
  • Sharp PA
  • Page DC
  • Jaenisch R


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

August 23, 2011

Associated Grants

  • Agency: NICHD NIH HHS, Id: 5-F32-HD051190
  • Agency: NICHD NIH HHS, Id: 5R01-HD045022
  • Agency: NCI NIH HHS, Id: 5R37CA084198
  • Agency: NCI NIH HHS, Id: P01-CA42063
  • Agency: NCI NIH HHS, Id: P30-CA14051
  • Agency: NIGMS NIH HHS, Id: R01-GM34277
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Apoptosis
  • Cell Count
  • Cell Cycle
  • Embryo Loss
  • Embryo, Mammalian
  • Female
  • Fertility
  • Gene Expression Regulation, Developmental
  • Germ Cells
  • Gonads
  • Infertility, Female
  • Male
  • Mice
  • Mice, Mutant Strains
  • MicroRNAs
  • Penetrance