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Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal lamination. However, the mechanisms by which retinal neurites are segregated within the inner or outer plexiform layers are not known. We find that the transmembrane semaphorins Sema5A and Sema5B constrain neurites from multiple retinal neuron subtypes within the inner plexiform layer (IPL). In Sema5A⁻/⁻; Sema5B⁻/⁻ mice, retinal ganglion cells (RGCs) and amacrine and bipolar cells exhibit severe defects leading to neurite mistargeting into the outer portions of the retina. These targeting abnormalities are more prominent in the outer (OFF) layers of the IPL and result in functional defects in select RGC response properties. Sema5A and Sema5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors both in vitro and in vivo. These findings define a set of ligands and receptors required for the establishment of inner retinal lamination and function.

Pubmed ID: 21835343

Authors

  • Matsuoka RL
  • Chivatakarn O
  • Badea TC
  • Samuels IS
  • Cahill H
  • Katayama K
  • Kumar SR
  • Suto F
  • Chédotal A
  • Peachey NS
  • Nathans J
  • Yoshida Y
  • Giger RJ
  • Kolodkin AL

Journal

Neuron

Publication Data

August 11, 2011

Associated Grants

  • Agency: NINDS NIH HHS, Id: F31NS056558-01A1
  • Agency: NINDS NIH HHS, Id: R01 NS047333
  • Agency: NINDS NIH HHS, Id: R01 NS065048
  • Agency: NINDS NIH HHS, Id: R01 NS065048
  • Agency: NINDS NIH HHS, Id: R01 NS35165
  • Agency: NINDS NIH HHS, Id: R37 NS035165
  • Agency: NINDS NIH HHS, Id: R37 NS035165-16
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Action Potentials
  • Animals
  • Axons
  • Cells, Cultured
  • Dendrites
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Neurites
  • Neurons
  • Photic Stimulation
  • Receptors, Cell Surface
  • Retina
  • Semaphorins