Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.

LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth and tumor suppression by phosphorylating and inhibiting the transcriptional coactivator YAP. LATS2 is activated by the MST2 kinase. How LATS2 is activated by MST2 in response to changes in cell density is unknown. Here we identify the angiomotin-family tight junction protein AMOTL2 as a novel activator of LATS2. Like AMOTL2, the other angiomotin-family proteins AMOT and AMOTL1 also activate LATS2 through a novel conserved domain that binds and activates LATS2. AMOTL2 binds MST2, LATS2, and YAP, suggesting that AMOTL2 might serve as a scaffold protein. We show that LATS2, AMOTL2, and YAP all localize to tight junctions, raising the possibility that clustering of Hippo pathway components at tight junctions might function to trigger LATS2 activation and growth inhibition in response to increased cell density.

Pubmed ID: 21832154 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Carrier Proteins | Cell Line, Tumor | Contact Inhibition | HEK293 Cells | Humans | Intercellular Signaling Peptides and Proteins | Membrane Proteins | Phosphoproteins | Phosphorylation | Protein Binding | Protein Structure, Tertiary | Protein-Serine-Threonine Kinases | RNA, Small Interfering | Signal Transduction | Tight Junctions | Tumor Suppressor Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM058406
  • Agency: NIGMS NIH HHS, Id: GM058406-12
  • Agency: Canadian Institutes of Health Research, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.