Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.

Immunity | Aug 26, 2011

Thymic stromal lymphopoetin (TSLP) influences numerous immune functions, including those in the colonic mucosa. Here we report that TSLP-deficient (Tslp(-/-)) mice did not exhibit increased inflammation during dextran sodium sulfate (DSS)-induced colitis but failed to recover from disease, resulting in death. Increased localized neutrophil elastase (NE) activity during overt inflammation was observed in Tslp(-/-) mice and was paralleled by reduced expression of an endogenous inhibitor, secretory leukocyte peptidase inhibitor (SLPI). Pharmacological inhibition of NE or treatment with rSLPI reduced DSS-induced mortality in Tslp(-/-) mice. Signaling through TSLPR on nonhematopoietic cells was sufficient for recovery from DSS-induced colitis. Expression of the receptor occurred on intestinal epithelial cells (IEC), with stimulation inducing SLPI expression. Therefore, TSLP is critical in mediating mucosal healing after insult and functions in a nonredundant capacity that is independent of restraining T helper 1 (Th1) and Th17 cell cytokine production.

Pubmed ID: 21820333 RIS Download

Mesh terms: Animals | Cells, Cultured | Colitis | Colon | Dextran Sulfate | Down-Regulation | Enzyme Activation | Immunity, Mucosal | Immunoglobulins | Inflammation | Intestinal Mucosa | Leukocyte Elastase | Mice | Mice, Knockout | Receptors, Cytokine | Recombinant Proteins | Secretory Leukocyte Peptidase Inhibitor | Signal Transduction

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAMS NIH HHS, Id: R01 AR056113
  • Agency: NIAID NIH HHS, Id: AI068731
  • Agency: NIAID NIH HHS, Id: R01 AI068731
  • Agency: NIAMS NIH HHS, Id: R01 AR056113-01A1
  • Agency: NIAID NIH HHS, Id: R01 AI068731-05
  • Agency: Canadian Institutes of Health Research, Id: AR056113
  • Agency: NIAMS NIH HHS, Id:

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.