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Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.

Science (New York, N.Y.) | Aug 5, 2011

Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation.

Pubmed ID: 21817055 RIS Download

Mesh terms: Animals | Axons | Binding Sites | Calcium-Binding Proteins | Cell Line | Cells, Cultured | GPI-Linked Proteins | Growth Cones | Humans | Immunohistochemistry | Ligands | Mice | Mice, Inbred ICR | Myelin Proteins | Nogo Proteins | Nogo Receptor 1 | Olfactory Pathways | Prosencephalon | Protein Binding | Receptors, Cell Surface | Signal Transduction

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Associated grants

  • Agency: NINDS NIH HHS, Id: R37 NS033020
  • Agency: NINDS NIH HHS, Id: R37 NS033020-19

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