Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.

Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation.

Pubmed ID: 21817055


  • Sato Y
  • Iketani M
  • Kurihara Y
  • Yamaguchi M
  • Yamashita N
  • Nakamura F
  • Arie Y
  • Kawasaki T
  • Hirata T
  • Abe T
  • Kiyonari H
  • Strittmatter SM
  • Goshima Y
  • Takei K


Science (New York, N.Y.)

Publication Data

August 5, 2011

Associated Grants

  • Agency: NINDS NIH HHS, Id: R37 NS033020
  • Agency: NINDS NIH HHS, Id: R37 NS033020-19

Mesh Terms

  • Animals
  • Axons
  • Binding Sites
  • Calcium-Binding Proteins
  • Cell Line
  • Cells, Cultured
  • GPI-Linked Proteins
  • Growth Cones
  • Humans
  • Immunohistochemistry
  • Ligands
  • Mice
  • Mice, Inbred ICR
  • Myelin Proteins
  • Olfactory Pathways
  • Prosencephalon
  • Protein Binding
  • Receptors, Cell Surface
  • Signal Transduction