Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.

Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation.

Pubmed ID: 21817055


  • Sato Y
  • Iketani M
  • Kurihara Y
  • Yamaguchi M
  • Yamashita N
  • Nakamura F
  • Arie Y
  • Kawasaki T
  • Hirata T
  • Abe T
  • Kiyonari H
  • Strittmatter SM
  • Goshima Y
  • Takei K


Science (New York, N.Y.)

Publication Data

August 5, 2011

Associated Grants

  • Agency: NINDS NIH HHS, Id: R37 NS033020
  • Agency: NINDS NIH HHS, Id: R37 NS033020-19

Mesh Terms

  • Animals
  • Axons
  • Binding Sites
  • Calcium-Binding Proteins
  • Cell Line
  • Cells, Cultured
  • GPI-Linked Proteins
  • Growth Cones
  • Humans
  • Immunohistochemistry
  • Ligands
  • Mice
  • Mice, Inbred ICR
  • Myelin Proteins
  • Olfactory Pathways
  • Prosencephalon
  • Protein Binding
  • Receptors, Cell Surface
  • Signal Transduction