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Evidence for network evolution in an Arabidopsis interactome map.

Science (New York, N.Y.) | Jul 29, 2011

http://www.ncbi.nlm.nih.gov/pubmed/21798944

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

Pubmed ID: 21798944 RIS Download

Mesh terms: 14-3-3 Proteins | Arabidopsis | Arabidopsis Proteins | Evolution, Molecular | Genes, Plant | Plant Growth Regulators | Protein Interaction Mapping | Proteome | Signal Transduction | Transcription Factors | Ubiquitination

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Associated grants

  • Agency: Biotechnology and Biological Sciences Research Council, Id: F005806
  • Agency: NHGRI NIH HHS, Id: F32 HG004098
  • Agency: NHGRI NIH HHS, Id: F32 HG004098-02
  • Agency: NHGRI NIH HHS, Id: F32 HG004830
  • Agency: NHGRI NIH HHS, Id: F32 HG004830-03
  • Agency: NHGRI NIH HHS, Id: F32HG004098
  • Agency: NHGRI NIH HHS, Id: F32HG004830
  • Agency: NIGMS NIH HHS, Id: R01 GM066025
  • Agency: NIGMS NIH HHS, Id: R01 GM066025-07
  • Agency: NHGRI NIH HHS, Id: R01 HG001715
  • Agency: NHGRI NIH HHS, Id: R01 HG001715-13
  • Agency: NIGMS NIH HHS, Id: R01GM066025
  • Agency: NHGRI NIH HHS, Id: R01HG001715

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