Evidence for network evolution in an Arabidopsis interactome map.
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
Pubmed ID: 21798944 RIS Download
14-3-3 Proteins | Arabidopsis | Arabidopsis Proteins | Evolution, Molecular | Genes, Plant | Plant Growth Regulators | Protein Interaction Mapping | Proteome | Signal Transduction | Transcription Factors | Ubiquitination