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ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions.

Genome biology | Nov 4, 2011

http://www.ncbi.nlm.nih.gov/pubmed/21787385

ZINBA (Zero-Inflated Negative Binomial Algorithm) identifies genomic regions enriched in a variety of ChIP-seq and related next-generation sequencing experiments (DNA-seq), calling both broad and narrow modes of enrichment across a range of signal-to-noise ratios. ZINBA models and accounts for factors that co-vary with background or experimental signal, such as G/C content, and identifies enrichment in genomes with complex local copy number variations. ZINBA provides a single unified framework for analyzing DNA-seq experiments in challenging genomic contexts.

Pubmed ID: 21787385 RIS Download

Mesh terms: Algorithms | Computer Simulation | DNA Copy Number Variations | Genomics | Models, Genetic | Models, Statistical | Sequence Analysis, DNA | Software

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