Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

Pubmed ID: 21775471


  • Shakes DC
  • Allen AK
  • Albert KM
  • Golden A



Publication Data

October 13, 2011

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R15GM60359

Mesh Terms

  • Alleles
  • Amino Acid Sequence
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Base Sequence
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Proliferation
  • Drosophila Proteins
  • Female
  • Genetic Complementation Test
  • Germ Cells
  • Male
  • Meiosis
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Sequence Homology, Amino Acid
  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligase Complexes