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emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.

Genetics | Oct 13, 2011

http://www.ncbi.nlm.nih.gov/pubmed/21775471

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

Pubmed ID: 21775471 RIS Download

Mesh terms: Alleles | Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Animals | Base Sequence | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cell Proliferation | Drosophila Proteins | Female | Genetic Complementation Test | Germ Cells | Male | Meiosis | Molecular Sequence Data | Mutation | Phenotype | Sequence Homology, Amino Acid | Tumor Suppressor Proteins | Ubiquitin-Protein Ligase Complexes