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emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

Pubmed ID: 21775471

Authors

  • Shakes DC
  • Allen AK
  • Albert KM
  • Golden A

Journal

Genetics

Publication Data

October 13, 2011

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R15GM60359

Mesh Terms

  • Alleles
  • Amino Acid Sequence
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Base Sequence
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Proliferation
  • Drosophila Proteins
  • Female
  • Genetic Complementation Test
  • Germ Cells
  • Male
  • Meiosis
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Sequence Homology, Amino Acid
  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligase Complexes