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emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.

Genetics | Oct 13, 2011

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

Pubmed ID: 21775471 RIS Download

Mesh terms: Alleles | Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Animals | Base Sequence | Caenorhabditis elegans | Caenorhabditis elegans Proteins | Cell Proliferation | Drosophila Proteins | Female | Genetic Complementation Test | Germ Cells | Male | Meiosis | Molecular Sequence Data | Mutation | Phenotype | Sequence Homology, Amino Acid | Tumor Suppressor Proteins | Ubiquitin-Protein Ligase Complexes

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R15 GM060359
  • Agency: NIGMS NIH HHS, Id: R15GM60359

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A central data repository for nematode biology including the complete genomic sequence, gene predictions and orthology assignments from a range of related nematodes. Derived from the initial ACeDB database of C. elegans genetic and sequence information, WormBase includes the genomic, anatomical and functional information of C. elegans, other Caenorhabditis species and other nematodes. WormBase maintains a public FTP site where researchers can find many commonly requested files and datasets, the WormBase software and prepackaged databases.

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