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Nuclear factor I/B is an oncogene in small cell lung cancer.

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.

Pubmed ID: 21764851

Authors

  • Dooley AL
  • Winslow MM
  • Chiang DY
  • Banerji S
  • Stransky N
  • Dayton TL
  • Snyder EL
  • Senna S
  • Whittaker CA
  • Bronson RT
  • Crowley D
  • Barretina J
  • Garraway L
  • Meyerson M
  • Jacks T

Journal

Genes & development

Publication Data

July 15, 2011

Associated Grants

  • Agency: NCI NIH HHS, Id: P30-CA14051
  • Agency: NHLBI NIH HHS, Id: T32 HL007627
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Animals
  • Animals, Genetically Modified
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Disease Models, Animal
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mice
  • NFI Transcription Factors
  • Oncogenes
  • Small Cell Lung Carcinoma