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Ank3-dependent SVZ niche assembly is required for the continued production of new neurons.

The rodent subventricular/subependymal zone (SVZ/SEZ) houses neural stem cells (NSCs) that generate olfactory bulb interneurons. It is unclear how the SVZ environment sustains neuronal production into adulthood. We discovered that the adapter molecule Ankyrin-3 (Ank3) is specifically upregulated in ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SVZ niche assembly through progenitor lateral adhesion. Furthermore, we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation, and genetic deletion of this pathway led to complete loss of SVZ niche structure. Interestingly, radial glia continued to transition into postnatal NSCs without this niche. However, inducible deletion of Foxj1-Ank3 from mature SVZ ependyma resulted in dramatic depletion of neurogenesis. Targeting a pathway regulating ependymal organization/assembly and showing its requirement for new neuron production, our results have important implications for environmental control of adult neurogenesis and harvesting NSCs for replacement therapy.

Pubmed ID: 21745638


  • Paez-Gonzalez P
  • Abdi K
  • Luciano D
  • Liu Y
  • Soriano-Navarro M
  • Rawlins E
  • Bennett V
  • Garcia-Verdugo JM
  • Kuo CT



Publication Data

July 14, 2011

Associated Grants

  • Agency: NIH HHS, Id: 1 DP2 OD004453-01
  • Agency: NIH HHS, Id: DP2 OD004453
  • Agency: NIH HHS, Id: DP2 OD004453-01
  • Agency: Medical Research Council, Id: G0900424
  • Agency: NINDS NIH HHS, Id: R01 NS078192

Mesh Terms

  • Animals
  • Ankyrins
  • Forkhead Transcription Factors
  • Lateral Ventricles
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Neural Stem Cells
  • Neurogenesis
  • Neuroglia
  • Stem Cell Niche
  • Stem Cells
  • Up-Regulation