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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

Cancer cell | Jul 12, 2011

Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not been delineated. We report here an animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays. Tet2 loss leads to a progressive enlargement of the hematopoietic stem cell compartment and eventual myeloproliferation in vivo, including splenomegaly, monocytosis, and extramedullary hematopoiesis. In addition, Tet2(+/-) mice also displayed increased stem cell self-renewal and extramedullary hematopoiesis, suggesting that Tet2 haploinsufficiency contributes to hematopoietic transformation in vivo.

Pubmed ID: 21723200 RIS Download

Mesh terms: Alleles | Animals | Cell Proliferation | Cell Transformation, Neoplastic | DNA-Binding Proteins | Gene Deletion | Gene Knockout Techniques | Gene Silencing | Haploinsufficiency | Hematopoiesis | Hematopoietic Stem Cells | Humans | Leukemia, Myelomonocytic, Chronic | Mice | Myeloid Cells | Proto-Oncogene Proteins

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Associated grants

  • Agency: NIA NIH HHS, Id: F31 AG039991
  • Agency: NCI NIH HHS, Id: P30 CA016087
  • Agency: NCI NIH HHS, Id: U54 CA143798
  • Agency: NCI NIH HHS, Id: P30 CA016087-30
  • Agency: NCI NIH HHS, Id: 5 P30CA16087-31
  • Agency: NCI NIH HHS, Id: R01 CA133379
  • Agency: NCI NIH HHS, Id: R01CA133379
  • Agency: NCI NIH HHS, Id: R01 CA129831
  • Agency: NCI NIH HHS, Id: 5P30CA16087-31
  • Agency: NCI NIH HHS, Id: R21CA141399
  • Agency: NCI NIH HHS, Id: CA129831-03S1
  • Agency: NCI NIH HHS, Id: R01 CA149655
  • Agency: NCI NIH HHS, Id: R01 CA105129
  • Agency: NCI NIH HHS, Id: R01 CA133379-04
  • Agency: NIA NIH HHS, Id: F31-AG039991
  • Agency: NCI NIH HHS, Id: 1R01CA138234-01
  • Agency: NIGMS NIH HHS, Id: R01GM088847
  • Agency: Howard Hughes Medical Institute, Id: R21 CA141399
  • Agency: NCI NIH HHS, Id: R01CA149655
  • Agency: NCI NIH HHS, Id: CA129831
  • Agency: NCI NIH HHS, Id: R01 CA105129-07
  • Agency: NCI NIH HHS, Id: R01CA105129
  • Agency: NCI NIH HHS, Id: R01 CA138234
  • Agency: NCI NIH HHS, Id: U54CA143798-01
  • Agency: NCI NIH HHS, Id: R01 GM088847
  • Agency: NIGMS NIH HHS, Id: R01 CA149655-03
  • Agency: NCI NIH HHS, Id:

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