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Sleep and synaptic homeostasis: structural evidence in Drosophila.

Science (New York, N.Y.) | Jun 24, 2011

http://www.ncbi.nlm.nih.gov/pubmed/21700878

The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary for synaptic renormalization. We found that, in three Drosophila neuronal circuits, synapse size or number increases after a few hours of wake and decreases only if flies are allowed to sleep. A richer wake experience resulted in both larger synaptic growth and greater sleep need. Finally, we demonstrate that the gene Fmr1 (fragile X mental retardation 1) plays an important role in sleep-dependent synaptic renormalization.

Pubmed ID: 21700878 RIS Download

Mesh terms: Animals | Dendrites | Drosophila Proteins | Drosophila melanogaster | Female | Fragile X Mental Retardation Protein | Homeostasis | Male | Mushroom Bodies | Neuronal Plasticity | Neurons | Neuropeptides | Sleep | Sleep Deprivation | Synapses | Time Factors

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Associated grants

  • Agency: NIH HHS, Id: DP1 OD000579
  • Agency: NIH HHS, Id: DP1 OD000579-05
  • Agency: NIGMS NIH HHS, Id: R01 GM075315
  • Agency: NIGMS NIH HHS, Id: R01 GM075315
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-01A2
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-02
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-03
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-04
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-05
  • Agency: NIGMS NIH HHS, Id: R01 GM075315-05S1
  • Agency: Canadian Institutes of Health Research, Id:

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