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Activation of visual pigments by light and heat.

Science (New York, N.Y.) | Jun 10, 2011

Vision begins with photoisomerization of visual pigments. Thermal energy can complement photon energy to drive photoisomerization, but it also triggers spontaneous pigment activation as noise that interferes with light detection. For half a century, the mechanism underlying this dark noise has remained controversial. We report here a quantitative relation between a pigment's photoactivation energy and its peak-absorption wavelength, λ(max). Using this relation and assuming that pigment activations by light and heat go through the same ground-state isomerization energy barrier, we can predict the relative noise of diverse pigments with multi-vibrational-mode thermal statistics. The agreement between predictions and our measurements strongly suggests that pigment noise arises from canonical isomerization. The predicted high noise for pigments with λ(max) in the infrared presumably explains why they apparently do not exist in nature.

Pubmed ID: 21659602 RIS Download

Mesh terms: Ambystoma | Animals | Bufo marinus | Goldfish | Hot Temperature | In Vitro Techniques | Light | Light Signal Transduction | Mice | Mice, Inbred C57BL | Photons | Retinal Cone Photoreceptor Cells | Retinal Pigments | Rhodopsin

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