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Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a <1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic strains coupled to the development of a CD101 knockout mouse. Susceptibility to T1D was correlated with genotype-dependent CD101 expression on multiple cell subsets, including Foxp3(+) regulatory CD4(+) T cells, CD11c(+) dendritic cells, and Gr1(+) myeloid cells. The correlation of CD101 expression on immune cells from four independent Idd10 haplotypes with the development of T1D supports the identity of Cd101 as Idd10. Because CD101 has been associated with regulatory T and Ag presentation cell functions, our results provide a further link between immune regulation and susceptibility to T1D.

Pubmed ID: 21613616


  • Rainbow DB
  • Moule C
  • Fraser HI
  • Clark J
  • Howlett SK
  • Burren O
  • Christensen M
  • Moody V
  • Steward CA
  • Mohammed JP
  • Fusakio ME
  • Masteller EL
  • Finger EB
  • Houchins JP
  • Naf D
  • Koentgen F
  • Ridgway WM
  • Todd JA
  • Bluestone JA
  • Peterson LB
  • Mattner J
  • Wicker LS


Journal of immunology (Baltimore, Md. : 1950)

Publication Data

July 1, 2011

Associated Grants

  • Agency: Wellcome Trust, Id: 079895
  • Agency: Wellcome Trust, Id: 091157
  • Agency: NIAID NIH HHS, Id: AI 15416
  • Agency: NIAID NIH HHS, Id: N01 AI015416
  • Agency: NIAID NIH HHS, Id: P01 AI039671
  • Agency: NIAID NIH HHS, Id: P01 AI039671-16
  • Agency: NIAID NIH HHS, Id: P01AI039671
  • Agency: NIDDK NIH HHS, Id: P30 DK078392
  • Agency: NIDDK NIH HHS, Id: P30 DK078392-01
  • Agency: NIDDK NIH HHS, Id: R01 DK084054
  • Agency: NIDDK NIH HHS, Id: R01 DK084054-03
  • Agency: NIDDK NIH HHS, Id: R01DK084054

Mesh Terms

  • Animals
  • Antigens, CD
  • Autoimmune Diseases
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Diabetes Mellitus, Type 1
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Mice
  • Mice, Congenic
  • Mice, Inbred A
  • Mice, Inbred C57BL
  • Mice, Inbred NOD
  • Mice, Knockout
  • Molecular Sequence Data