Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chromatin environment present at the regulatory regions of developmental genes that contains both H3K4 di/trimethylation and H3K27 trimethylation marks. LSD1 occupies the promoters of a subset of developmental genes that contain bivalent domains and are co-occupied by OCT4 and NANOG in human embryonic stem cells, where it controls the levels of H3K4 methylation through its demethylase activity. Thus, LSD1 has a role in maintaining the silencing of several developmental genes in human embryonic stem cells by regulating the critical balance between H3K4 and H3K27 methylation at their regulatory regions.

Pubmed ID: 21602794


  • Adamo A
  • Sesé B
  • Boue S
  • Castaño J
  • Paramonov I
  • Barrero MJ
  • Izpisua Belmonte JC


Nature cell biology

Publication Data

June 2, 2011

Associated Grants


Mesh Terms

  • Apoptosis
  • Bone Morphogenetic Protein 2
  • Cell Cycle
  • Cell Differentiation
  • Cell Line
  • Embryonic Stem Cells
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Histone Demethylases
  • Humans
  • Jumonji Domain-Containing Histone Demethylases
  • Methylation
  • Pluripotent Stem Cells
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction