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LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

Nature cell biology | Jun 2, 2011

We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chromatin environment present at the regulatory regions of developmental genes that contains both H3K4 di/trimethylation and H3K27 trimethylation marks. LSD1 occupies the promoters of a subset of developmental genes that contain bivalent domains and are co-occupied by OCT4 and NANOG in human embryonic stem cells, where it controls the levels of H3K4 methylation through its demethylase activity. Thus, LSD1 has a role in maintaining the silencing of several developmental genes in human embryonic stem cells by regulating the critical balance between H3K4 and H3K27 methylation at their regulatory regions.

Pubmed ID: 21602794 RIS Download

Mesh terms: Apoptosis | Bone Morphogenetic Protein 2 | Cell Cycle | Cell Differentiation | Cell Line | Embryonic Stem Cells | Gene Expression Regulation, Developmental | Gene Knockdown Techniques | Histone Demethylases | Humans | Jumonji Domain-Containing Histone Demethylases | Methylation | Pluripotent Stem Cells | Reverse Transcriptase Polymerase Chain Reaction | Signal Transduction

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