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A user's guide to the encyclopedia of DNA elements (ENCODE).

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

Pubmed ID: 21526222


  • ENCODE Project Consortium


PLoS biology

Publication Data

April 28, 2011

Associated Grants

  • Agency: Wellcome Trust, Id: 095908
  • Agency: NIDDK NIH HHS, Id: R01 DK054369
  • Agency: NIDDK NIH HHS, Id: R01 DK065806
  • Agency: NHGRI NIH HHS, Id: R01 HG003143
  • Agency: NHGRI NIH HHS, Id: R01 HG004037
  • Agency: NHGRI NIH HHS, Id: RC2 HG005573

Mesh Terms

  • Base Sequence
  • Chromatin
  • Conserved Sequence
  • DNA Methylation
  • DNA-Binding Proteins
  • Databases, Nucleic Acid
  • Gene Components
  • Gene Expression Regulation
  • Genome, Human
  • Humans
  • Internet
  • Models, Genetic
  • Quality Control
  • RNA, Messenger
  • RNA-Binding Proteins