• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

The relationship between lower urinary tract symptom severity and sleep disturbance in the CAMUS trial.

PURPOSE: Bothersome lower urinary tract symptoms, including nocturia, significantly impact general health related quality of life in men, as does sleep disturbance. However, few groups have examined the relationship between urinary symptom severity and sleep disturbance. MATERIALS AND METHODS: Men enrolled in a clinical trial of saw palmetto (Serenoa repens) were studied at baseline. Lower urinary tract symptom severity, as determined by the American Urological Association symptom index and quality of life scores, and the degree of sleep disturbance were determined by the Jenkins sleep scale. Analysis was done, adjusting for baseline characteristics, to identify predictors of severe sleep disturbance. RESULTS: A total of 366 men with a mean ± SD age of 60.9 ± 8.3 years who had moderate-severe lower urinary tract symptoms (mean American Urological Association symptom index score 14.58 ± 4.6 points) and a mean Jenkins sleep score of 7.3 ± 4.7 points were included in analysis. Overall there were significant associations between the American Urological Association symptom index score and sleep disturbance severity. Multivariate analysis revealed that obstructive and irritative symptoms were significantly associated with severe sleep disturbance. Further analysis showed that lower serum prostate specific antigen and post-void residual urine volume were also significantly associated with the degree of sleep disturbance. CONCLUSIONS: Lower urinary tract symptom severity is a risk factor for severe sleep disturbance in men. While nocturia was significantly associated with sleep disturbance, other lower urinary tract symptoms were also independent predictors of sleep dysfunction.

Pubmed ID: 21497839

Authors

  • Helfand BT
  • McVary KT
  • Meleth S
  • Sharp V
  • Foster H
  • Naslund M
  • Williams OD
  • CAMUS Study Group

Journal

The Journal of urology

Publication Data

June 12, 2011

Associated Grants

  • Agency: NIDDK NIH HHS, Id: U01 DK063795
  • Agency: NIDDK NIH HHS, Id: U01 DK63778
  • Agency: NIDDK NIH HHS, Id: U01 DK63788
  • Agency: NIDDK NIH HHS, Id: U01 DK63795
  • Agency: NIDDK NIH HHS, Id: U01 DK63797
  • Agency: NIDDK NIH HHS, Id: U01 DK63831
  • Agency: NIDDK NIH HHS, Id: U01 DK63833
  • Agency: NIDDK NIH HHS, Id: U01 DK63835
  • Agency: NIDDK NIH HHS, Id: U01 DK63840
  • Agency: NIDDK NIH HHS, Id: U01 DK63862
  • Agency: NIDDK NIH HHS, Id: U01 DK63866

Mesh Terms

  • Humans
  • Male
  • Middle Aged
  • Plant Extracts
  • Prostatic Hyperplasia
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index
  • Sleep Disorders
  • Urologic Diseases