Generation of induced pluripotent stem cells (iPSCs) and converting one cell type to another (transdifferentiation) by manipulating the expression of a small number of genes highlight the progress of cellular reprogramming, which holds great promise for regenerative medicine. A key challenge is to find the recipes of perturbing genes to achieve successful reprogramming such that the reprogrammed cells function in the same way as the natural cells.
Pubmed ID: 21486480 RIS Download
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Software application that finds starting points for MCMC analysis performed on large, complex pedigrees and polymorphic markers. (entry from Genetic Analysis Software)
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