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AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected individuals. Nonetheless, blockade of the renin-angiotensin system (RAS) lowers BP in the majority of patients with hypertension. Despite its apparent role in hypertension pathogenesis, the key cellular targets of the RAS that control BP have not been clearly identified. Here we demonstrate that RAS actions in the epithelium of the proximal tubule have a critical and nonredundant role in determining the level of BP. Abrogation of AT(1) angiotensin receptor signaling in the proximal tubule alone is sufficient to lower BP, despite intact vascular responses. Elimination of this pathway reduces proximal fluid reabsorption and alters expression of key sodium transporters, modifying pressure-natriuresis and providing substantial protection against hypertension. Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension.

Pubmed ID: 21459331


  • Gurley SB
  • Riquier-Brison AD
  • Schnermann J
  • Sparks MA
  • Allen AM
  • Haase VH
  • Snouwaert JN
  • Le TH
  • McDonough AA
  • Koller BH
  • Coffman TM


Cell metabolism

Publication Data

April 6, 2011

Associated Grants

  • Agency: NHLBI NIH HHS, Id: 2R01 HL056122
  • Agency: NIDDK NIH HHS, Id: DK083785
  • Agency: NIDDK NIH HHS, Id: R01 DK081646
  • Agency: NIDDK NIH HHS, Id: R01 DK083785
  • Agency: NHLBI NIH HHS, Id: R01 HL056122
  • Agency: NHLBI NIH HHS, Id: R01 HL056122-14

Mesh Terms

  • Animals
  • Blood Pressure
  • Hypertension
  • Kidney Tubules, Proximal
  • Mice
  • Receptor, Angiotensin, Type 1
  • Renin-Angiotensin System
  • Signal Transduction
  • Sodium
  • Sodium-Hydrogen Antiporter
  • Sodium-Potassium-Chloride Symporters
  • Solute Carrier Family 12, Member 1