We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Cell metabolism | Apr 6, 2011

Hypertension affects more than 1.5 billion people worldwide but the precise cause of elevated blood pressure (BP) cannot be determined in most affected individuals. Nonetheless, blockade of the renin-angiotensin system (RAS) lowers BP in the majority of patients with hypertension. Despite its apparent role in hypertension pathogenesis, the key cellular targets of the RAS that control BP have not been clearly identified. Here we demonstrate that RAS actions in the epithelium of the proximal tubule have a critical and nonredundant role in determining the level of BP. Abrogation of AT(1) angiotensin receptor signaling in the proximal tubule alone is sufficient to lower BP, despite intact vascular responses. Elimination of this pathway reduces proximal fluid reabsorption and alters expression of key sodium transporters, modifying pressure-natriuresis and providing substantial protection against hypertension. Thus, effectively targeting epithelial functions of the proximal tubule of the kidney should be a useful therapeutic strategy in hypertension.

Pubmed ID: 21459331 RIS Download

Mesh terms: Animals | Blood Pressure | Hypertension | Kidney Tubules, Proximal | Mice | Receptor, Angiotensin, Type 1 | Renin-Angiotensin System | Signal Transduction | Sodium | Sodium-Hydrogen Antiporter | Sodium-Potassium-Chloride Symporters | Solute Carrier Family 12, Member 1

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: R01 DK083785
  • Agency: NHLBI NIH HHS, Id: R01 HL056122-14
  • Agency: NIDDK NIH HHS, Id: R01 DK081646
  • Agency: NHLBI NIH HHS, Id: R01 HL056122
  • Agency: NIDDK NIH HHS, Id: DK083785
  • Agency: NHLBI NIH HHS, Id: 2R01 HL056122

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.