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Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer.

BMC medicine | 2011

Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degree of malignancy, and hence acts as a prognostic and predictive indicator of the disease. Furthermore, though the atypical nuclear morphology of cancer cells is believed to be a consequence of oncogenic signaling, the molecular basis remains unclear. Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established.

Pubmed ID: 21439080 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA83638
  • Agency: NCI NIH HHS, United States
    Id: R01 CA079716
  • Agency: NCI NIH HHS, United States
    Id: CA79716
  • Agency: NCI NIH HHS, United States
    Id: R01 CA140323
  • Agency: NCI NIH HHS, United States
    Id: R01 CA099471
  • Agency: NCI NIH HHS, United States
    Id: R01 CA095071

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Cell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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