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The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by previous reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.
Pubmed ID: 21407270 RIS Download
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Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsThe EQUATOR Network is an international initiative that seeks to enhance reliability and value of medical research literature by promoting transparent and accurate reporting of research studies. This goal will be achieved through: raising awareness of the crucial importance of good reporting of research becoming the recognised global centre providing resources, education and training relating to the reporting of health research and use of reporting guidelines assisting in the development, dissemination and implementation of reporting guidelines monitoring the status of the quality of reporting across health research literature conducting research relating to the quality of reporting The EQUATOR Network Resource Centre provides up-to-date resources related to health research reporting mainly for: authors of research articles journal editors and peer reviewers reporting guideline developers Other users that benefit from the knowledge of principles of good research reporting include representatives of research funders, research ethics committee members, individuals and organisations involved in research education. The resources on our website are regularly updated (see the date of the last update at the foot of each page). Sponsor. Core programme funding for 2007 - 2013 NHS National Library for Health NHS National Institute for Health Research NHS National Knowledge Service UK Medical Research Council Canadian Institutes of Health Research Scottish Chief Scientist Office Pan American Health Organization
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