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Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome.

Diabetes | 2011

Hyperuricemia is strongly associated with obesity and metabolic syndrome and can predict visceral obesity and insulin resistance. Previously, we showed that soluble uric acid directly stimulated the redox-dependent proinflammatory signaling in adipocytes. In this study we demonstrate the role of hyperuricemia in the production of key adipokines.

Pubmed ID: 21346177 RIS Download

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL068607
  • Agency: NHLBI NIH HHS, United States
    Id: HL-68607

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C57BL/6NCrl (tool)

RRID:IMSR_CRL:027

Mus musculus with name C57BL/6NCrl from IMSR.

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3T3-L1 (tool)

RRID:CVCL_0123

Cell line 3T3-L1 is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)

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