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CESTA, a positive regulator of brassinosteroid biosynthesis.

Brassinosteroids (BRs) are steroid hormones that are essential for the development of plants. A tight control of BR homeostasis is vital for modulating their impact on growth responses. Although it is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required BR levels, our knowledge of the mechanisms governing feedback control is limited. In this study, we identify the transcription factor CESTA as a regulator of BR biosynthesis. ces-D was isolated in a screen of Arabidopsis mutants by BR over-accumulation phenotypes. Loss-of-function analysis and the use of a dominant repressor version revealed functional overlap among CESTA and its homologues and confirmed the role of CESTA in the positive control of BR-biosynthetic gene expression. We provide evidence that CESTA interacts with its homologue BEE1 and can directly bind to a G-box motif in the promoter of the BR biosynthesis gene CPD. Moreover, we show that CESTA subnuclear localization is BR regulated and discuss a model, in which CESTA interplays with BEE1 to control BR biosynthesis and other BR responses.

Pubmed ID: 21336258


  • Poppenberger B
  • Rozhon W
  • Khan M
  • Husar S
  • Adam G
  • Luschnig C
  • Fujioka S
  • Sieberer T


The EMBO journal

Publication Data

March 16, 2011

Associated Grants


Mesh Terms

  • Arabidopsis
  • Arabidopsis Proteins
  • Biosynthetic Pathways
  • Brassinosteroids
  • Cholestanols
  • Gene Expression Regulation
  • Plant Growth Regulators
  • Protein Interaction Mapping
  • Steroids, Heterocyclic
  • Transcription Factors