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Actin structure and function.

Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and participates in more protein-protein interactions than any known protein. These properties, along with its ability to transition between monomeric (G-actin) and filamentous (F-actin) states under the control of nucleotide hydrolysis, ions, and a large number of actin-binding proteins, make actin a critical player in many cellular functions, ranging from cell motility and the maintenance of cell shape and polarity to the regulation of transcription. Moreover, the interaction of filamentous actin with myosin forms the basis of muscle contraction. Owing to its central role in the cell, the actin cytoskeleton is also disrupted or taken over by numerous pathogens. Here we review structures of G-actin and F-actin and discuss some of the interactions that control the polymerization and disassembly of actin.

Pubmed ID: 21314430


  • Dominguez R
  • Holmes KC


Annual review of biophysics

Publication Data

May 6, 2011

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM073791
  • Agency: NHLBI NIH HHS, Id: HL086655
  • Agency: NIMH NIH HHS, Id: MH087950
  • Agency: NHLBI NIH HHS, Id: P01 HL086655
  • Agency: NHLBI NIH HHS, Id: P01 HL086655-05
  • Agency: NIGMS NIH HHS, Id: R01 GM073791
  • Agency: NIGMS NIH HHS, Id: R01 GM073791-08
  • Agency: NIMH NIH HHS, Id: R01 MH087950
  • Agency: NIMH NIH HHS, Id: R01 MH087950-03

Mesh Terms

  • Actins
  • Binding Sites
  • Computer Simulation
  • Models, Biological
  • Models, Chemical
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship