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A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Science (New York, N.Y.) | Mar 11, 2011

http://www.ncbi.nlm.nih.gov/pubmed/21252314

Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-λ expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-λ-mediated immune response to control bacterial colonization of the host.

Pubmed ID: 21252314 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Cell Line | Cell Line, Tumor | Cell Nucleus | Chromatin | Chromosomal Proteins, Non-Histone | Down-Regulation | Gene Expression Profiling | Gene Expression Regulation | Host-Pathogen Interactions | Humans | Interferons | Interleukins | Listeria monocytogenes | Listeriosis | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Molecular Sequence Data | Signal Transduction | Virulence Factors

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Associated grants

  • Agency: European Research Council, Id: 233348

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