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Cell size and growth rate are major determinants of replicative lifespan.

Yeast cells, like mammalian cells, enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of the relationship between size and cellular lifespan is not well understood. Herein, we report a genetic link between cell size, growth rate and lifespan. Mutations that increase cell size concomitantly increase growth rate and decrease lifespan. As a result, large cells grow, divide and age dramatically faster than small cells. Conversely, small cell mutants age slowly and are long-lived. Investigation of the mechanisms involved suggests that attainment of a maximal size modulates lifespan. Indeed, cumulative results revealed that life expectancy is size-dependent, and that the rate at which cells age is determined in large part by the amount of cell growth per generation.

Pubmed ID: 21248481

Authors

  • Yang J
  • Dungrawala H
  • Hua H
  • Manukyan A
  • Abraham L
  • Lane W
  • Mead H
  • Wright J
  • Schneider BL

Journal

Cell cycle (Georgetown, Tex.)

Publication Data

January 1, 2011

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01GM077874
  • Agency: NIGMS NIH HHS, Id: R01GM077874-04S1
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Cell Aging
  • Cell Division
  • Cell Enlargement
  • Cell Proliferation
  • Cell Size
  • Mutation
  • Yeasts