Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development.

We have previously demonstrated that Gpr177, the mouse orthologue of Drosophila Wls/Evi/Srt, is required for establishment of the anterior-posterior axis. The Gpr177 null phenotype is highly reminiscent to the loss of Wnt3, the earliest abnormality among all Wnt knockouts in mice. The expression of Gpr177 in various cell types and tissues lead us to hypothesize that reciprocal regulation of Wnt and Gpr177 is essential for the Wnt-dependent developmental and pathogenic processes. Here, we create a new mouse strain permitting conditional inactivation of Gpr177. The loss of Gpr177 in the Wnt1-expressing cells causes mid/hindbrain and craniofacial defects which are far more severe than the Wnt1 knockout, but resemble the double knockout of Wnt1 and Wnt3a as well as β-catenin deletion in the Wnt1-expressing cells. Our findings demonstrate the importance of Gpr177 in Wnt1-mediated development of the mouse embryo, suggesting an overlapping function of Wnt family members in the Wnt1-expressing cells.

Pubmed ID: 21246653


  • Fu J
  • Ivy Yu HM
  • Maruyama T
  • Mirando AJ
  • Hsu W


Developmental dynamics : an official publication of the American Association of Anatomists

Publication Data

February 19, 2011

Associated Grants

  • Agency: NCI NIH HHS, Id: CA106308
  • Agency: NIDCR NIH HHS, Id: DE015654
  • Agency: NCI NIH HHS, Id: R01 CA106308
  • Agency: NCI NIH HHS, Id: R01 CA106308-05
  • Agency: NIDCR NIH HHS, Id: R01 DE015654
  • Agency: NIDCR NIH HHS, Id: R01 DE015654-03
  • Agency: NIDCR NIH HHS, Id: R01 DE015654-04
  • Agency: NIDCR NIH HHS, Id: R01 DE015654-05

Mesh Terms

  • Animals
  • Brain
  • Craniofacial Abnormalities
  • Facial Bones
  • Gene Knockdown Techniques
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Mice, Transgenic
  • Receptors, G-Protein-Coupled
  • Skull
  • Wnt Proteins
  • Wnt1 Protein
  • Wnt3 Protein
  • Wnt3A Protein