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A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.

Neural development | 2011

The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal topographic axon connections between thalamus and cortex. The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets. However, the cellular and molecular components mediating these steps remain poorly understood.

Pubmed ID: 21214893 RIS Download

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Associated grants

  • Agency: NIMH NIH HHS, United States
    Id: R01 MH086147
  • Agency: Howard Hughes Medical Institute, United States
  • Agency: NIMH NIH HHS, United States
    Id: K01MH69647
  • Agency: NICHD NIH HHS, United States
    Id: HD36404
  • Agency: NINDS NIH HHS, United States
    Id: R01NS35129
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS31558
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS031558
  • Agency: NICHD NIH HHS, United States
    Id: U01 HD43430
  • Agency: NIMH NIH HHS, United States
    Id: K01 MH069647

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