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Heterogeneous integration of adult-generated granule cells into the epileptic brain.

The functional impact of adult-generated granule cells in the epileptic brain is unclear, with data supporting both protective and maladaptive roles. These conflicting findings could be explained if new granule cells integrate heterogeneously, with some cells taking neutral or adaptive roles and others contributing to recurrent circuitry supporting seizures. Here, we tested this hypothesis by completing detailed morphological characterizations of age- and experience-defined cohorts of adult-generated granule cells from transgenic mice. The majority of newborn cells exposed to an epileptogenic insult exhibited reductions in dendritic spine number, suggesting reduced excitatory input to these cells. A significant subset, however, exhibited higher spine numbers. These latter cells tended to have enlarged cell bodies, long basal dendrites, or both. Moreover, cells with basal dendrites received significantly more recurrent mossy fiber input through their apical dendrites, indicating that these cells are robustly integrated into the pathological circuitry of the epileptic brain. These data imply that newborn cells play complex--and potentially conflicting--roles in epilepsy.

Pubmed ID: 21209195


  • Murphy BL
  • Pun RY
  • Yin H
  • Faulkner CR
  • Loepke AW
  • Danzer SC


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

January 5, 2011

Associated Grants

  • Agency: NINDS NIH HHS, Id: R01 NS062806
  • Agency: NINDS NIH HHS, Id: R01 NS062806-01A1
  • Agency: NINDS NIH HHS, Id: R01 NS062806-02
  • Agency: NINDS NIH HHS, Id: R01 NS062806-03
  • Agency: NINDS NIH HHS, Id: R01 NS065020
  • Agency: NINDS NIH HHS, Id: R01 NS065020-01
  • Agency: NINDS NIH HHS, Id: R01 NS065020-02
  • Agency: NINDS NIH HHS, Id: R01 NS065020-03
  • Agency: NINDS NIH HHS, Id: R01NS062806
  • Agency: NINDS NIH HHS, Id: R01NS065020

Mesh Terms

  • Adult Stem Cells
  • Animals
  • Animals, Newborn
  • Antigens, Thy-1
  • Cation Transport Proteins
  • Cell Count
  • Dendrites
  • Dendritic Spines
  • Disease Models, Animal
  • Green Fluorescent Proteins
  • Hippocampus
  • Imaging, Three-Dimensional
  • Kruppel-Like Transcription Factors
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microscopy, Confocal
  • Neurogenesis
  • Neurons
  • Pilocarpine
  • Statistics, Nonparametric
  • Status Epilepticus