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The Genomic HyperBrowser: inferential genomics at the sequence level.

The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to statistical analysis of sequence-level genomic information. We provide a growing collection of generic biological investigations that query pairwise relations between tracks, represented as mathematical objects, along the genome. The Genomic HyperBrowser implements the approach and is available at http://hyperbrowser.uio.no.

Pubmed ID: 21182759

Authors

  • Sandve GK
  • Gundersen S
  • Rydbeck H
  • Glad IK
  • Holden L
  • Holden M
  • Liestøl K
  • Clancy T
  • Ferkingstad E
  • Johansen M
  • Nygaard V
  • Tøstesen E
  • Frigessi A
  • Hovig E

Journal

Genome biology

Publication Data

March 2, 2010

Associated Grants

None

Mesh Terms

  • Base Pairing
  • Computational Biology
  • Exons
  • Gene Expression
  • Genome
  • Genomics
  • Histones
  • Models, Biological
  • Nucleic Acid Denaturation
  • Polymorphism, Single Nucleotide
  • Sequence Analysis
  • Software