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The developmental transcriptome of Drosophila melanogaster.

Nature | Mar 24, 2011

Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and RNA editing directs the development of this complex organism. Here we used RNA-Seq, tiling microarrays and cDNA sequencing to explore the transcriptome in 30 distinct developmental stages. We identified 111,195 new elements, including thousands of genes, coding and non-coding transcripts, exons, splicing and editing events, and inferred protein isoforms that previously eluded discovery using established experimental, prediction and conservation-based approaches. These data substantially expand the number of known transcribed elements in the Drosophila genome and provide a high-resolution view of transcriptome dynamics throughout development.

Pubmed ID: 21179090 RIS Download

Mesh terms: Alternative Splicing | Animals | Base Sequence | Drosophila Proteins | Drosophila melanogaster | Exons | Female | Gene Expression Profiling | Gene Expression Regulation, Developmental | Genes, Insect | Genome, Insect | Male | MicroRNAs | Oligonucleotide Array Sequence Analysis | Protein Isoforms | RNA Editing | RNA, Messenger | RNA, Small Untranslated | Sequence Analysis | Sex Characteristics | Transcription, Genetic

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Associated grants

  • Agency: NHGRI NIH HHS, Id: U01 HG004271
  • Agency: NHGRI NIH HHS, Id: U01 HG004271-01
  • Agency: Howard Hughes Medical Institute, Id: ZIA DK015600-14
  • Agency: Intramural NIH HHS, Id: U01 HB004271
  • Agency: NHLBI NIH HHS, Id:

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