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Cortical representations of olfactory input by trans-synaptic tracing.

In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map. However, it is unclear how this map is represented in the olfactory cortex. Here we combine rabies-virus-dependent retrograde mono-trans-synaptic labelling with genetics to control the location, number and type of 'starter' cortical neurons, from which we trace their presynaptic neurons. We find that individual cortical neurons receive input from multiple mitral cells representing broadly distributed glomeruli. Different cortical areas represent the olfactory bulb input differently. For example, the cortical amygdala preferentially receives dorsal olfactory bulb input, whereas the piriform cortex samples the whole olfactory bulb without obvious bias. These differences probably reflect different functions of these cortical areas in mediating innate odour preference or associative memory. The trans-synaptic labelling method described here should be widely applicable to mapping connections throughout the mouse nervous system.

Pubmed ID: 21179085

Authors

  • Miyamichi K
  • Amat F
  • Moussavi F
  • Wang C
  • Wickersham I
  • Wall NR
  • Taniguchi H
  • Tasic B
  • Huang ZJ
  • He Z
  • Callaway EM
  • Horowitz MA
  • Luo L

Journal

Nature

Publication Data

April 14, 2011

Associated Grants

  • Agency: NIMH NIH HHS, Id: R01 MH063912
  • Agency: NINDS NIH HHS, Id: R01 NS050835
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Amygdala
  • Animals
  • Axons
  • Bias (Epidemiology)
  • Brain Mapping
  • HEK293 Cells
  • Humans
  • Mice
  • Mice, Transgenic
  • Neuroanatomical Tract-Tracing Techniques
  • Odors
  • Olfactory Bulb
  • Olfactory Pathways
  • Olfactory Perception
  • Olfactory Receptor Neurons
  • Rabies virus
  • Synapses