• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation.

Pubmed ID: 21177974

Authors

  • modENCODE Consortium
  • Roy S
  • Ernst J
  • Kharchenko PV
  • Kheradpour P
  • Negre N
  • Eaton ML
  • Landolin JM
  • Bristow CA
  • Ma L
  • Lin MF
  • Washietl S
  • Arshinoff BI
  • Ay F
  • Meyer PE
  • Robine N
  • Washington NL
  • Di Stefano L
  • Berezikov E
  • Brown CD
  • Candeias R
  • Carlson JW
  • Carr A
  • Jungreis I
  • Marbach D
  • Sealfon R
  • Tolstorukov MY
  • Will S
  • Alekseyenko AA
  • Artieri C
  • Booth BW
  • Brooks AN
  • Dai Q
  • Davis CA
  • Duff MO
  • Feng X
  • Gorchakov AA
  • Gu T
  • Henikoff JG
  • Kapranov P
  • Li R
  • MacAlpine HK
  • Malone J
  • Minoda A
  • Nordman J
  • Okamura K
  • Perry M
  • Powell SK
  • Riddle NC
  • Sakai A
  • Samsonova A
  • Sandler JE
  • Schwartz YB
  • Sher N
  • Spokony R
  • Sturgill D
  • van Baren M
  • Wan KH
  • Yang L
  • Yu C
  • Feingold E
  • Good P
  • Guyer M
  • Lowdon R
  • Ahmad K
  • Andrews J
  • Berger B
  • Brenner SE
  • Brent MR
  • Cherbas L
  • Elgin SC
  • Gingeras TR
  • Grossman R
  • Hoskins RA
  • Kaufman TC
  • Kent W
  • Kuroda MI
  • Orr-Weaver T
  • Perrimon N
  • Pirrotta V
  • Posakony JW
  • Ren B
  • Russell S
  • Cherbas P
  • Graveley BR
  • Lewis S
  • Micklem G
  • Oliver B
  • Park PJ
  • Celniker SE
  • Henikoff S
  • Karpen GH
  • Lai EC
  • MacAlpine DM
  • Stein LD
  • White KP
  • Kellis M

Journal

Science (New York, N.Y.)

Publication Data

December 24, 2010

Associated Grants

  • Agency: NHGRI NIH HHS, Id: R01 HG004037
  • Agency: NHGRI NIH HHS, Id: R01HG004037
  • Agency: NHGRI NIH HHS, Id: RC2HG005639
  • Agency: NHGRI NIH HHS, Id: U01 HG004258
  • Agency: NHGRI NIH HHS, Id: U01 HG004271
  • Agency: NHGRI NIH HHS, Id: U01 HG004279
  • Agency: NHGRI NIH HHS, Id: U01HG004258
  • Agency: NHGRI NIH HHS, Id: U01HG004261
  • Agency: NHGRI NIH HHS, Id: U01HG004264
  • Agency: NHGRI NIH HHS, Id: U01HG004271
  • Agency: NHGRI NIH HHS, Id: U01HG004274
  • Agency: NHGRI NIH HHS, Id: U01HG004279
  • Agency: NHGRI NIH HHS, Id: U41HG004269
  • Agency: Intramural NIH HHS, Id: ZIA DK015600-14
  • Agency: Howard Hughes Medical Institute, Id:

Mesh Terms

  • Animals
  • Binding Sites
  • Chromatin
  • Computational Biology
  • Drosophila Proteins
  • Drosophila melanogaster
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Genes, Insect
  • Genome, Insect
  • Genomics
  • Histones
  • Molecular Sequence Annotation
  • Nucleosomes
  • Promoter Regions, Genetic
  • RNA, Small Untranslated
  • Transcription Factors
  • Transcription, Genetic