Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

An embedded subnetwork of highly active neurons in the neocortex.

VIDEO ABSTRACT: Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP(-) neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP(+) neurons. Paired-cell recordings indicated that fosGFP(+) neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.

Pubmed ID: 21172607


  • Yassin L
  • Benedetti BL
  • Jouhanneau JS
  • Wen JA
  • Poulet JF
  • Barth AL



Publication Data

December 22, 2010

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA0171-88
  • Agency: NIDA NIH HHS, Id: R01 DA017188
  • Agency: NIDA NIH HHS, Id: R01 DA017188-04
  • Agency: NIDA NIH HHS, Id: R01 DA017188-05
  • Agency: NIDA NIH HHS, Id: R01 DA017188-06A2

Mesh Terms

  • Action Potentials
  • Animals
  • Animals, Newborn
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neocortex
  • Nerve Net
  • Neurons