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Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation.

The Journal of cell biology | 2010

Stem cells depend on signals from cells within their microenvironment, or niche, as well as factors secreted by distant cells to regulate their maintenance and function. Here we show that Boi, a Hedgehog (Hh)-binding protein, is a novel suppressor of proliferation of follicle stem cells (FSCs) in the Drosophila ovary. Hh is expressed in apical cells, distant from the FSC niche, and diffuses to reach FSCs, where it promotes FSC proliferation. We show that Boi is expressed in apical cells and exerts its suppressive effect on FSC proliferation by binding to and sequestering Hh on the apical cell surface, thereby inhibiting Hh diffusion. Our studies demonstrate that cells distant from the local niche can regulate stem cell function through ligand sequestration, a mechanism that likely is conserved in other epithelial tissues.

Pubmed ID: 21098113 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: CA06927
  • Agency: NINDS NIH HHS, United States
    Id: R21 NS053775
  • Agency: NINDS NIH HHS, United States
    Id: NS053775
  • Agency: NIDDK NIH HHS, United States
    Id: DK07644301
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD065800
  • Agency: NCI NIH HHS, United States
    Id: P30 CA006927
  • Agency: NIDDK NIH HHS, United States
    Id: F32 DK076443

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Intergovernmental organisation funded by public research money from its member states in Europe. Groups and laboratories perform basic research in molecular biology and molecular medicine, training for scientists, students and visitors. Provides development of services, new instruments and methods, data and technology in its member states.

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SD (tool)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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