Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Multiple autism-like behaviors in a novel transgenic mouse model.

Autism spectrum disorder (ASD) diagnoses are behaviorally based with no defined universal biomarkers, occur at a 1:110 ratio in the population, and predominantly affect males compared to females at approximately a 4:1 ratio. One approach to investigate and identify causes of ASD is to use organisms that display abnormal behavioral responses that model ASD-related impairments. This study describes a novel transgenic mouse, MALTT, which was generated using a forward genetics approach. It was determined that the transgene integrated within a non-coding region on the X chromosome. The MALTT line exhibited a complete repertoire of ASD-like behavioral deficits in all three domains required for an ASD diagnosis: reciprocal social interaction, communication, and repetitive or inflexible behaviors. Specifically, MALTT male mice showed deficits in social interaction and interest, abnormalities in pup and juvenile ultrasonic vocalization communications, and exhibited a repetitive stereotypy. Abnormalities were also observed in the domain of sensory function, a secondary phenotype prevalently associated with ASD. Mapping and expression studies suggested that the Fam46 gene family may be linked to the observed ASD-related behaviors. The MALTT line provides a unique genetic model for examining the underlying biological mechanisms involved in ASD-related behaviors.

Pubmed ID: 21093492


  • Hamilton SM
  • Spencer CM
  • Harrison WR
  • Yuva-Paylor LA
  • Graham DF
  • Daza RA
  • Hevner RF
  • Overbeek PA
  • Paylor R


Behavioural brain research

Publication Data

March 17, 2011

Associated Grants

  • Agency: NICHD NIH HHS, Id: P30 HD024064
  • Agency: NICHD NIH HHS, Id: P30 HD024064-23

Mesh Terms

  • Aggression
  • Analysis of Variance
  • Animals
  • Autistic Disorder
  • Disease Models, Animal
  • Female
  • Male
  • Mice
  • Mice, Transgenic
  • Sensory Gating
  • Social Behavior
  • Stereotyped Behavior
  • Vocalization, Animal